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Accessed October Accessed July Devkota, B. Updated May Direct Antiglobulin Test. Medscape Reference [On-line information]. Hemolytic Disease of Newborn.
Vorvick, L. Updated February 7. Zieve, D. Updated August Rh incompatibility. The Children's Hospital of Philadelphia [On-line information].
Pagana, K. McPherson R, Pincus M, eds. Oct 29, Schick P. Hemolytic Anemia Workup. Types of Hemolytic Anemia. This form enables patients to ask specific questions about lab tests.
Your questions will be answered by a laboratory scientist as part of a voluntary service provided by one of our partners, American Society for Clinical Laboratory Science.
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Choose Topic At a Glance What is being tested? Also Known As. This article was last reviewed on July 1, This article was last modified on December 24, At a Glance.
Why Get Tested? When To Get Tested? When you have had a blood transfusion recently and are experiencing symptoms of a transfusion reaction, such as dizziness, back pain, dark urine, shortness of breath When a newborn shows signs of hemolytic disease of the newborn When you have symptoms of increased destruction of your red blood cells, which may include feeling tired more often than usual, shortness of breath, headaches, paleness and your healthcare practitioner wants to find out if this happens because your immune system mistakenly makes antibodies that destroy your red blood cells.
Sample Required? A blood sample drawn from a vein in your arm. Test Preparation Needed? Looking for Test Results? Looking for Reference Ranges?
What is being tested? There are a few reasons why RBCs may be attacked by antibodies: Following a blood transfusion : If someone receives a donor's blood that does not fully match their own type, their body will make antibodies that recognize the donor's RBC as foreign.
For more on blood types, see the article on Blood Typing. People who have many blood transfusions are more likely to make antibodies to RBCs because they are exposed to more foreign RBC.
If someone shows symptoms of a reaction after a transfusion, a DAT will be performed to determine if those antibodies have attached to RBCs.
During pregnancy or labor, the mother may be exposed to the baby's RBCs. Autoimmune diseases and other conditions : Some people make antibodies that target their own RBCs autoantibodies.
These antibodies are produced because the immune system mistakenly recognizes their own RBCs as foreign. Some examples of conditions that cause this include: Autoimmune disorders such as lupus Malignant diseases such as lymphoma and chronic lymphocytic leukemia Infections such as mycoplasma pneumonia and mononucleosis Drug-induced anemia : Certain drugs can induce antibodies against RBCs and therefore cause their destruction hemolysis.
This is seen with some antibiotics, such as penicillin, cephalosporins and piperacillin. Be sure to tell your healthcare provider about any drugs you have been taking recently.
If the healthcare provider suspects drug-induced autoimmune anemia, the suspect medication will be discontinued. Symptoms typically resolve promptly after the drug is discontinued.
See More. See Less. Accordion Title. How is the test used? A DAT may also be used to investigate a suspected transfusion reaction.
For more on these, see the "What is being tested? When is it ordered? What does the test result mean? Some examples of conditions that can cause a positive DAT include: Transfusion reaction Autoimmune disorder , such as lupus Lymphoma or other malignant disease Infection, such as mycoplasma pneumonia and mononucleosis Medication, such as penicillin Baby-mother blood group incompatibility For more information about these, see the "What is being tested?
Can I get antibodies from donating blood? No, you will not be exposed to anyone else's blood while donating. If a mother has an incompatibility with one child, will she have them with all of her children?
Is there anything else I should know? Related Content. On This Site Tests. Transfusion Medicine. MedlinePlus Medical Encyclopedia: Rh incompatibility.
March of Dimes Fact Sheet: Rh disease. View Sources. Coral Blood Services. Bangor, Maine. First Name. Last Name. Email Address.
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Thank you for using the Consumer Information Response Service "the Service" to inquire about the meaning of your lab test results.
Although the laboratory provides the largest single source of objective, scientific data on patient status, it is only one part of a complex biological picture of health or disease.
As professional clinical laboratory scientists, our goal is to assist you in understanding the purpose of laboratory tests and the general meaning of your laboratory results.
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